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Titel:

Propofol Affects Cortico-Hippocampal Interactions via β3 Subunit-Containing GABAA Receptors.

Dokumenttyp:
Article; Journal Article
Autor(en):
Kreuzer, Matthias; Butovas, Sergejus; García, Paul S; Schneider, Gerhard; Schwarz, Cornelius; Rudolph, Uwe; Antkowiak, Bernd; Drexler, Berthold
Abstract:
BACKGROUND: General anesthetics depress neuronal activity. The depression and uncoupling of cortico-hippocampal activity may contribute to anesthetic-induced amnesia. However, the molecular targets involved in this process are not fully characterized. GABAA receptors, especially the type with β3 subunits, represent a main molecular target of propofol. We therefore hypothesized that GABAA receptors with β3 subunits mediate the propofol-induced disturbance of cortico-hippocampal interactions. METH...     »
Zeitschriftentitel:
Int J Mol Sci
Jahr:
2020
Band / Volume:
21
Heft / Issue:
16
Volltext / DOI:
doi:10.3390/ijms21165844
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32823959
Print-ISSN:
1422-0067
TUM Einrichtung:
Klinik für Anästhesiologie (DHM)
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