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Title:

Neurotoxicity of different amyloid beta subspecies in mice and their interaction with isoflurane anaesthesia.

Document type:
Article; Journal Article
Author(s):
Borgstedt, Laura; Blobner, Manfred; Musiol, Maximilian; Bratke, Sebastian; Syryca, Finn; Rammes, Gerhard; Jungwirth, Bettina; Schmid, Sebastian
Abstract:
BACKGROUND: The aim of this study was to assess different amyloid beta subspecies' effects on behaviour and cognition in mice and their interaction with isoflurane anaesthesia. METHODS: After governmental approval, cannulas were implanted in the lateral cerebral ventricle. After 14 days the mice were randomly intracerebroventricularly injected with Aβ 1-40 (Aβ40), Aβ 1-42 (Aβ42), 3NTyr10-Aβ (Aβ nitro), AβpE3-42 (Aβ pyro), or phosphate buffered saline. Four days after the injection, 30 mice (6 an...     »
Journal title abbreviation:
PLoS ONE
Year:
2020
Journal volume:
15
Journal issue:
12
Fulltext / DOI:
doi:10.1371/journal.pone.0242989
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/33270674
Print-ISSN:
1932-6203
TUM Institution:
Klinik für Anästhesiologie (DHM)
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