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Titel:

Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma.

Dokumenttyp:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Schmidts, Andrea; Ormhøj, Maria; Choi, Bryan D; Taylor, Allison O; Bouffard, Amanda A; Scarfò, Irene; Larson, Rebecca C; Frigault, Matthew J; Gallagher, Kathleen; Castano, Ana P; Riley, Lauren S; Cabral, Maria L; Boroughs, Angela C; Velasco Cárdenas, Rubí M-H; Schamel, Wolfgang; Zhou, Jing; Mackay, Sean; Tai, Yu-Tzu; Anderson, Kenneth C; Maus, Marcela V
Abstract:
Chimeric antigen receptor (CAR) T cells (CARTs) have shown tremendous potential for the treatment of certain B-cell malignancies, including patients with relapsed/refractory multiple myeloma (MM). Targeting the B-cell maturation antigen (BCMA) has produced the most promising results for CART therapy of MM to date, but not all remissions are sustained. Emergence of BCMA escape variants has been reported under the selective pressure of monospecific anti-BCMA CART treatment. Thus, there is a clinic...     »
Zeitschriftentitel:
Blood Adv
Jahr:
2019
Band / Volume:
3
Heft / Issue:
21
Seitenangaben Beitrag:
3248-3260
Volltext / DOI:
doi:10.1182/bloodadvances.2019000703
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31698455
Print-ISSN:
2473-9529
TUM Einrichtung:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie
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