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Titel:

XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.

Dokumenttyp:
Letter
Autor(en):
Müller, Nicole; Fischer, Julius C; Yabal, Monica; Haas, Tobias; Poeck, Hendrik; Jost, Philipp J
Abstract:
Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the secretion of elevated levels of proinflammatory cytokines during engraftment when BIRC4 is absent.
Zeitschriftentitel:
Eur J Immunol
Jahr:
2019
Band / Volume:
49
Heft / Issue:
3
Seitenangaben Beitrag:
504-507
Sprache:
eng
Volltext / DOI:
doi:10.1002/eji.201847818
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30585320
Print-ISSN:
0014-2980
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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