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Title:

Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Schmidts, Andrea; Ormhøj, Maria; Choi, Bryan D; Taylor, Allison O; Bouffard, Amanda A; Scarfò, Irene; Larson, Rebecca C; Frigault, Matthew J; Gallagher, Kathleen; Castano, Ana P; Riley, Lauren S; Cabral, Maria L; Boroughs, Angela C; Velasco Cárdenas, Rubí M-H; Schamel, Wolfgang; Zhou, Jing; Mackay, Sean; Tai, Yu-Tzu; Anderson, Kenneth C; Maus, Marcela V
Abstract:
Chimeric antigen receptor (CAR) T cells (CARTs) have shown tremendous potential for the treatment of certain B-cell malignancies, including patients with relapsed/refractory multiple myeloma (MM). Targeting the B-cell maturation antigen (BCMA) has produced the most promising results for CART therapy of MM to date, but not all remissions are sustained. Emergence of BCMA escape variants has been reported under the selective pressure of monospecific anti-BCMA CART treatment. Thus, there is a clinic...     »
Journal title abbreviation:
Blood Adv
Year:
2019
Journal volume:
3
Journal issue:
21
Pages contribution:
3248-3260
Fulltext / DOI:
doi:10.1182/bloodadvances.2019000703
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31698455
Print-ISSN:
2473-9529
TUM Institution:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie
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