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Title:

Dynamic Profiling of Antitumor Activity of CAR T Cells Using Micropatterned Tumor Arrays.

Document type:
Article; Journal Article
Author(s):
Wang, Xiao; Scarfò, Irene; Schmidts, Andrea; Toner, Mehmet; Maus, Marcela V; Irimia, Daniel
Abstract:
Cancer immunotherapy based on the engineering of chimeric antigen receptors (CAR) on T cells has emerged as one of the most promising new therapies for patients with B-cell malignancies. Preclinical assessments of essential CAR T cell functions such as trafficking and cytotoxicity are critical for accelerating the development of highly effective therapeutic candidates. However, current tools for evaluating CAR-T functions lack sufficient precision. Here, a micropatterned tumor array (MiTA) is de...     »
Journal title abbreviation:
Adv Sci (Weinh)
Year:
2019
Journal volume:
6
Journal issue:
23
Fulltext / DOI:
doi:10.1002/advs.201901829
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31832320
TUM Institution:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie
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