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Title:

CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity.

Document type:
Article; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Choi, Bryan D; Yu, Xiaoling; Castano, Ana P; Bouffard, Amanda A; Schmidts, Andrea; Larson, Rebecca C; Bailey, Stefanie R; Boroughs, Angela C; Frigault, Matthew J; Leick, Mark B; Scarfò, Irene; Cetrulo, Curtis L; Demehri, Shadmehr; Nahed, Brian V; Cahill, Daniel P; Wakimoto, Hiroaki; Curry, William T; Carter, Bob S; Maus, Marcela V
Abstract:
Chimeric antigen receptor (CAR)-T-cell therapy for solid tumors is limited due to heterogeneous target antigen expression and outgrowth of tumors lacking the antigen targeted by CAR-T cells directed against single antigens. Here, we developed a bicistronic construct to drive expression of a CAR specific for EGFRvIII, a glioblastoma-specific tumor antigen, and a bispecific T-cell engager (BiTE) against EGFR, an antigen frequently overexpressed in glioblastoma but also expressed in normal tissues....     »
Journal title abbreviation:
Nat Biotechnol
Year:
2019
Journal volume:
37
Journal issue:
9
Pages contribution:
1049-1058
Fulltext / DOI:
doi:10.1038/s41587-019-0192-1
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31332324
Print-ISSN:
1087-0156
TUM Institution:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie
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