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- Title:
XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.
- Document type:
- Letter
- Author(s):
- Müller, Nicole; Fischer, Julius C; Yabal, Monica; Haas, Tobias; Poeck, Hendrik; Jost, Philipp J
- Abstract:
- Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the secretion of elevated levels of proinflammatory cytokines during engraftment when BIRC4 is absent.
- Journal title abbreviation:
- Eur J Immunol
- Year:
- 2019
- Journal volume:
- 49
- Journal issue:
- 3
- Pages contribution:
- 504-507
- Language:
- eng
- Fulltext / DOI:
- doi:10.1002/eji.201847818
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/30585320
- Print-ISSN:
- 0014-2980
- TUM Institution:
- III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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