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Titel:

Dynamic Profiling of Antitumor Activity of CAR T Cells Using Micropatterned Tumor Arrays.

Dokumenttyp:
Article; Journal Article
Autor(en):
Wang, Xiao; Scarfò, Irene; Schmidts, Andrea; Toner, Mehmet; Maus, Marcela V; Irimia, Daniel
Abstract:
Cancer immunotherapy based on the engineering of chimeric antigen receptors (CAR) on T cells has emerged as one of the most promising new therapies for patients with B-cell malignancies. Preclinical assessments of essential CAR T cell functions such as trafficking and cytotoxicity are critical for accelerating the development of highly effective therapeutic candidates. However, current tools for evaluating CAR-T functions lack sufficient precision. Here, a micropatterned tumor array (MiTA) is de...     »
Zeitschriftentitel:
Adv Sci (Weinh)
Jahr:
2019
Band / Volume:
6
Heft / Issue:
23
Volltext / DOI:
doi:10.1002/advs.201901829
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31832320
TUM Einrichtung:
Klinik und Poliklinik für Innere Medizin III, Hämatologie und Onkologie
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