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Titel:

Functional identity of hypothalamic melanocortin neurons depends on Tbx3.

Dokumenttyp:
Journal Article
Autor(en):
Quarta, Carmelo; Fisette, Alexandre; Xu, Yanjun; Colldén, Gustav; Legutko, Beata; Tseng, Yu-Ting; Reim, Alexander; Wierer, Michael; De Rosa, Maria Caterina; Klaus, Valentina; Rausch, Rick; Thaker, Vidhu V; Graf, Elisabeth; Strom, Tim M; Poher, Anne-Laure; Gruber, Tim; Le Thuc, Ophélia; Cebrian-Serrano, Alberto; Kabra, Dhiraj; Bellocchio, Luigi; Woods, Stephen C; Pflugfelder, Gert O; Nogueiras, Rubén; Zeltser, Lori; Grunwald Kadow, Ilona C; Moon, Anne; García-Cáceres, Cristina; Mann, Matthias; Tr...     »
Abstract:
Heterogeneous populations of hypothalamic neurons orchestrate energy balance via the release of specific signatures of neuropeptides. However, how specific intracellular machinery controls peptidergic identities and function of individual hypothalamic neurons remains largely unknown. The transcription factor T-box 3 (Tbx3) is expressed in hypothalamic neurons sensing and governing energy status, whereas human TBX3 haploinsufficiency has been linked with obesity. Here, we demonstrate that loss of...     »
Zeitschriftentitel:
Nat Metab
Jahr:
2019
Band / Volume:
1
Heft / Issue:
2
Seitenangaben Beitrag:
222-235
Volltext / DOI:
doi:10.1038/s42255-018-0028-1
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/32694784
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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