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Titel:

Dusp8 affects hippocampal size and behavior in mice and humans.

Dokumenttyp:
Journal Article
Autor(en):
Baumann, Peter; Schriever, Sonja C; Kullmann, Stephanie; Zimprich, Annemarie; Feuchtinger, Annette; Amarie, Oana; Peter, Andreas; Walch, Axel; Gailus-Durner, Valerie; Fuchs, Helmut; Hrabě de Angelis, Martin; Wurst, Wolfgang; Tschöp, Matthias H; Heni, Martin; Hölter, Sabine M; Pfluger, Paul T
Abstract:
Dual-specificity phosphatase 8 (Dusp8) acts as physiological inhibitor for the MAPKs Jnk, Erk and p38 which are involved in regulating multiple CNS processes. While Dusp8 expression levels are high in limbic areas such as the hippocampus, the functional role of Dusp8 in hippocampus morphology, MAPK-signaling, neurogenesis and apoptosis as well as in behavior are still unclear. It is of particular interest whether human carriers of a DUSP8 allelic variant show similar hippocampal alterations to m...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2019
Band / Volume:
9
Heft / Issue:
1
Volltext / DOI:
doi:10.1038/s41598-019-55527-7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31862894
Print-ISSN:
2045-2322
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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