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Title:

Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity.

Document type:
Journal Article
Author(s):
Jall, Sigrid; De Angelis, Meri; Lundsgaard, Anne-Marie; Fritzen, Andreas M; Nicolaisen, Trine S; Klein, Anders B; Novikoff, Aaron; Sachs, Stephan; Richter, Erik A; Kiens, Bente; Schramm, Karl-Werner; Tschöp, Matthias H; Stemmer, Kerstin; Clemmensen, Christoffer; Müller, Timo D; Kleinert, Maximilian
Abstract:
AIMS/HYPOTHESIS: Treatment with the α3β4 nicotinic acetylcholine receptor (nAChR) agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), improves glucose tolerance in diet-induced obese (DIO) mice, but the physiological and molecular mechanisms are unknown. METHODS: DMPP (10 mg/kg body weight, s.c.) was administered either in a single injection (acute) or daily for up to 14 days (chronic) in DIO wild-type (WT) and Chrnb4 knockout (KO) mice and glucose tolerance, tissue-specific tracer-based g...     »
Journal title abbreviation:
Diabetologia
Year:
2020
Journal volume:
63
Journal issue:
6
Pages contribution:
1236-1247
Fulltext / DOI:
doi:10.1007/s00125-020-05117-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32140744
Print-ISSN:
0012-186X
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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