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Titel:

Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates.

Dokumenttyp:
Journal Article; Review
Autor(en):
Knerr, Patrick J; Mowery, Stephanie A; Finan, Brian; Perez-Tilve, Diego; Tschöp, Matthias H; DiMarchi, Richard D
Abstract:
The continued global growth in the prevalence of obesity coupled with the limited number of efficacious and safe treatment options elevates the importance of innovative pharmaceutical approaches. Combinatorial strategies that harness the metabolic benefits of multiple hormonal mechanisms have emerged at the preclinical and more recently clinical stages of drug development. A priority has been anti-obesity unimolecular peptides that function as balanced, high potency poly-agonists at two or all t...     »
Zeitschriftentitel:
Peptides
Jahr:
2020
Band / Volume:
125
Volltext / DOI:
doi:10.1016/j.peptides.2019.170225
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31786282
Print-ISSN:
0196-9781
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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