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Titel:

Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation.

Dokumenttyp:
Journal Article
Autor(en):
Lundsgaard, Anne-Marie; Fritzen, Andreas M; Nicolaisen, Trine S; Carl, Christian S; Sjøberg, Kim A; Raun, Steffen H; Klein, Anders B; Sanchez-Quant, Eva; Langer, Jakob; Ørskov, Cathrine; Clemmensen, Christoffer; Tschöp, Matthias H; Richter, Erik A; Kiens, Bente; Kleinert, Maximilian
Abstract:
Excessive circulating FAs have been proposed to promote insulin resistance (IR) of glucose metabolism by increasing the oxidation of FAs over glucose. Therefore, inhibition of FA oxidation (FAOX) has been suggested to ameliorate IR. However, prolonged inhibition of FAOX would presumably cause lipid accumulation and thereby promote lipotoxicity. To understand the glycemic consequences of acute and prolonged FAOX inhibition, we treated mice with the carnitine palmitoyltransferase 1 (CPT-1) inhibit...     »
Zeitschriftentitel:
J Lipid Res
Jahr:
2020
Band / Volume:
61
Heft / Issue:
1
Seitenangaben Beitrag:
10-19
Volltext / DOI:
doi:10.1194/jlr.RA119000177
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/31719103
Print-ISSN:
0022-2275
TUM Einrichtung:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)
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