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Title:

The Oncolytic Adenovirus XVir-N-31 as a Novel Therapy in Muscle-Invasive Bladder Cancer.

Document type:
Journal Article
Author(s):
Lichtenegger, Eva; Koll, Florestan; Haas, Helena; Mantwill, Klaus; Janssen, Klaus-Peter; Laschinger, Melanie; Gschwend, Jürgen; Steiger, Katja; Black, Peter; Moskalev, Igor; Nawroth, Roman; Holm, Per Sonne
Abstract:
Muscle-invasive bladder cancer represents approximately 25% of diagnosed bladder cancer cases and carries a significant risk of death. Oncolytic viruses are novel antitumor agents with the ability to selectively replicate and lyse tumor cells while sparing healthy tissue. We explored the efficiency of the oncolytic YB-1-selective adenovirus XVir-N-31 in vitro and in an orthotopic mouse model for bladder cancer by intramural injection under ultrasound guidance. We demonstrated that XVir-N-31 repl...     »
Journal title abbreviation:
Hum Gene Ther
Year:
2019
Journal volume:
30
Journal issue:
1
Pages contribution:
44-56
Language:
eng
Fulltext / DOI:
doi:10.1089/hum.2018.026
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/29916265
Print-ISSN:
1043-0342
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Urologische Klinik und Poliklinik
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