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Title:

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Tardif, Jean-Claude; Kouz, Simon; Waters, David D; Bertrand, Olivier F; Diaz, Rafael; Maggioni, Aldo P; Pinto, Fausto J; Ibrahim, Reda; Gamra, Habib; Kiwan, Ghassan S; Berry, Colin; López-Sendón, José; Ostadal, Petr; Koenig, Wolfgang; Angoulvant, Denis; Grégoire, Jean C; Lavoie, Marc-André; Dubé, Marie-Pierre; Rhainds, David; Provencher, Mylène; Blondeau, Lucie; Orfanos, Andreas; L'Allier, Philippe L; Guertin, Marie-Claude; Roubille, François
Abstract:
BACKGROUND: Experimental and clinical evidence supports the role of inflammation in atherosclerosis and its complications. Colchicine is an orally administered, potent antiinflammatory medication that is indicated for the treatment of gout and pericarditis. METHODS: We performed a randomized, double-blind trial involving patients recruited within 30 days after a myocardial infarction. The patients were randomly assigned to receive either low-dose colchicine (0.5 mg once daily) or placebo. The pr...     »
Journal title abbreviation:
N Engl J Med
Year:
2019
Journal volume:
381
Journal issue:
26
Pages contribution:
2497-2505
Fulltext / DOI:
doi:10.1056/NEJMoa1912388
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31733140
Print-ISSN:
0028-4793
TUM Institution:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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