Association of growth differentiation factor 15 with other key biomarkers, functional parameters and mortality in community-dwelling older adults.

Rothenbacher, Dietrich; Dallmeier, Dhayana; Christow, Hannes; Koenig, Wolfgang; Denkinger, Michael; Klenk, Jochen; Bohm, B.; Geiger, H.; Stingl, J.; Riepe, M.; Rapp, K.; Scharffetter-Kochanek, K.; Steinacker, J. M.; Ludolph, A.; von Arnim, C.; Nagel, G.; Weinmayr, G.; Peter, R.

doi:10.1093/ageing/afz022

2019

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Document type:: Article
Author(s):: Rothenbacher, Dietrich; Dallmeier, Dhayana; Christow, Hannes; Koenig, Wolfgang; Denkinger, Michael; Klenk, Jochen; Bohm, B.; Geiger, H.; Stingl, J.; Riepe, M.; Rapp, K.; Scharffetter-Kochanek, K.; Steinacker, J. M.; Ludolph, A.; von Arnim, C.; Nagel, G.; Weinmayr, G.; Peter, R.
Title:: Association of growth differentiation factor 15 with other key biomarkers, functional parameters and mortality in community-dwelling older adults.
Abstract:: BACKGROUND: Growth differentiation factor 15 (GDF-15) has been associated with many adverse age-related outcomes and other age-related disorders. The aim of the study was to investigate if baseline levels of GDF-15 are associated with total mortality in community living, older adults during eight years of follow-up after simultaneous consideration of key biomarkers and functional parameters. METHODS: prospective cohort study including 1,470 community-dwelling older adults aged 65 years or older. GDF-15 was measured by ElectroChemi-Lumisnescence Immunoassays (Roche, Mannheim, Germany). We used Cox-proportional hazards regression to estimate the association of GDF-15 levels with 8-year all-cause mortality. RESULTS: GDF-15 levels were independently of age and sex strongly associated with many biomarkers such as CRP, IL-6, NT-proBNP, hs-troponines as well as with lipids, metabolic and endocrine markers and kidney function (all P-values < 0.001). GDF-15 showed also a statistically significant correlation to gait speed, hand grip strength and walking duration. In addition, we found a consistent association between levels of GDF-15 and risk of subsequent all-cause mortality which persisted after additional adjustment for key markers of inflammation, cardiac function and damage, and physical function. The hazard ratio (HR) per unit increase of log-transformed GDF-15 was 1.72 (95% CI 1.35; 2.18). CONCLUSIONS: GDF-15 levels were not only strongly associated with many functional parameters and key biomarkers independently of age and sex, but also with 8-year all-cause mortality even after adjusting for gait speed, NT-proBNP and hs-TnT.
Journal title abbreviation:: Age Ageing
Year:: 2019
Journal volume:: 48
Journal issue:: 4
Pages contribution:: 541-546
Fulltext / DOI:: doi:10.1093/ageing/afz022
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/30855645
Print-ISSN:: 0002-0729
TUM Institution:: Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Lehr- und Forschungskooperationen mit den Kliniken und Instituten am Deutschen Herzzentrum Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (DHM) (Prof. Schunkert)2019