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- Document type:
- Article; Journal Article
- Author(s):
- Johannsen, Katharina; Flechtner-Mors, Marion; Kratzer, Wolfgang; Koenig, Wolfgang; Boehm, Bernhard Otto; Schmidberger, Julian
- Title:
- Association Between Visfatin and Hepatic Steatosis in the General Population During Long-Term Follow-Up.
- Abstract:
- The aim of this study was to investigate any association between the adipose tissue-derived protein, visfatin, and non-alcoholic fatty liver disease (NAFLD) and its potential long-term impact on hepatic steatosis. A cross-sectional study including 2429 randomly selected subjects was performed in 2002. Later, 403 subjects were re-evaluated in 2013. Serum visfatin concentrations were determined by sandwich enzyme-linked immunosorbent assay. Phenotyping included abdominal ultrasonography, anthropometric data, and laboratory investigations. No association was found between circulating visfatin levels and the presence of NAFLD at baseline (2002: p=0.0967) or during follow-up (2013: p=0.1312). However, a significant increase in visfatin levels in relation to the level of steatosis was seen during follow-up (p<0.0001). During the more than 10-year follow-up, the metabolic status of the study subjects worsened, with a significant increase in body mass index (BMI) (p<0.0001), waist-to-hip ratio (p<0.0001), triglycerides (TG) (p<0.0001), low-density lipoprotein (p=0.0305), homeostasis model assessment (p<0.0001), and presence of diabetes (p<0.0001). This change was accompanied by an increase in serum visfatin levels, which showed a weak correlation with BMI (p<0.0001, r=0.27586) and presence of diabetes (p<0.0043, r=0.14188). A statistically significant correlation between leucocyte numbers and serum visfatin concentration (p<0.0001, r=0.25615) was found. We found no association between visfatin levels and the presence or absence of NAFLD or the degree of hepatic fatty infiltration at baseline. There was a strong correlation between serum visfatin concentrations and the number of leucocytes, which may suggest a proinflammatory role for visfatin.
- Journal title abbreviation:
- Horm Metab Res
- Year:
- 2019
- Journal volume:
- 51
- Journal issue:
- 9
- Pages contribution:
- 602-607
- Fulltext / DOI:
- doi:10.1055/a-0897-8565
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/31132798
- Print-ISSN:
- 0018-5043
- TUM Institution:
- Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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