Association between objective response rate and overall survival in metastatic neuroendocrine tumors treated with radioembolization: a systematic literature review and regression analysis.

Pollock, Richard F; Brennan, Victoria K; Peters, Ralph; Paprottka, Philipp M

doi:10.1080/14737140.2020.1814748

2020

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Title:: Association between objective response rate and overall survival in metastatic neuroendocrine tumors treated with radioembolization: a systematic literature review and regression analysis.
Document type:: Review; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Systematic Review
Author(s):: Pollock, Richard F; Brennan, Victoria K; Peters, Ralph; Paprottka, Philipp M
Abstract:: OBJECTIVES: Neuroendocrine tumors (NETs) are a heterogeneous group of cancers arising from neuroendocrine cells. The aim was to evaluate objective response rate (ORR) as a predictor of overall survival (OS) in patients with metastatic NETs (mNETs) treated with radioembolization (RE). METHODS: Randomized controlled trials and observational studies of RE treatment of mNETs were identified by systematic literature review (SLR). Pooled ORR and OS estimates were calculated and a weighted generalized linear model (GLM) of ORR as a predictor of OS was derived, stratified by ORR assessment criteria and RE type (Yttrium-90 resin or glass microspheres). RESULTS: The SLR identified 32 observational studies. Mean ORR was 41% (95% confidence interval 38-45%). The Yttrium-90 resin and glass microsphere GLMs accounted for 59% and 57% of OS deviance, respectively. ORR was a significant predictor of OS in the resin microspheres model (p < 0.001), but not the glass microspheres model (p = 0.11). CONCLUSIONS: A weighted GLM showed a significant relationship between ORR and OS in patients with mNETs treated with Yttrium-90 resin microspheres. ORR could therefore potentially be an OS surrogate in future trials of Yttrium-90 resin microspheres. Further research is needed to confirm the relationship between ORR and OS and the difference between resin and glass microspheres.
Journal title abbreviation:: Expert Rev Anticancer Ther
Year:: 2020
Journal volume:: 20
Journal issue:: 11
Pages contribution:: 997-1009
Fulltext / DOI:: doi:10.1080/14737140.2020.1814748
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/32930618
Print-ISSN:: 1473-7140
TUM Institution:: Professur für Interventionelle Radiologie (Prof. Paprottka)
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mediaTUM Gesamtbestand Hochschulbibliographie 2020 Fakultäten Medizin Institut für Radiologie

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)Professur für Interventionelle Radiologie (Prof. Paprottka)2020