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- Title:
Association between objective response rate and overall survival in metastatic neuroendocrine tumors treated with radioembolization: a systematic literature review and regression analysis.
- Document type:
- Review; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Systematic Review
- Author(s):
- Pollock, Richard F; Brennan, Victoria K; Peters, Ralph; Paprottka, Philipp M
- Abstract:
- OBJECTIVES: Neuroendocrine tumors (NETs) are a heterogeneous group of cancers arising from neuroendocrine cells. The aim was to evaluate objective response rate (ORR) as a predictor of overall survival (OS) in patients with metastatic NETs (mNETs) treated with radioembolization (RE). METHODS: Randomized controlled trials and observational studies of RE treatment of mNETs were identified by systematic literature review (SLR). Pooled ORR and OS estimates were calculated and a weighted generalized linear model (GLM) of ORR as a predictor of OS was derived, stratified by ORR assessment criteria and RE type (Yttrium-90 resin or glass microspheres). RESULTS: The SLR identified 32 observational studies. Mean ORR was 41% (95% confidence interval 38-45%). The Yttrium-90 resin and glass microsphere GLMs accounted for 59% and 57% of OS deviance, respectively. ORR was a significant predictor of OS in the resin microspheres model (p < 0.001), but not the glass microspheres model (p = 0.11). CONCLUSIONS: A weighted GLM showed a significant relationship between ORR and OS in patients with mNETs treated with Yttrium-90 resin microspheres. ORR could therefore potentially be an OS surrogate in future trials of Yttrium-90 resin microspheres. Further research is needed to confirm the relationship between ORR and OS and the difference between resin and glass microspheres.
- Journal title abbreviation:
- Expert Rev Anticancer Ther
- Year:
- 2020
- Journal volume:
- 20
- Journal issue:
- 11
- Pages contribution:
- 997-1009
- Fulltext / DOI:
- doi:10.1080/14737140.2020.1814748
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/32930618
- Print-ISSN:
- 1473-7140
- TUM Institution:
- Professur für Interventionelle Radiologie (Prof. Paprottka)
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