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Title:

Combined DCE-MRI- and FDG-PET enable histopathological grading prediction in a rat model of hepatocellular carcinoma.

Document type:
Journal Article
Author(s):
Kaissis, Georgios A; Lohöfer, Fabian K; Hörl, Marie; Heid, Irina; Steiger, Katja; Munoz-Alvarez, Kim Agnes; Schwaiger, Markus; Rummeny, Ernst J; Weichert, Wilko; Paprottka, Philipp; Braren, Rickmer
Abstract:
PURPOSE: To test combined dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and 18F-FDG positron emission tomography (FDG-PET)-derived parameters for prediction of histopathological grading in a rat Diethyl Nitrosamine (DEN)-induced hepatocellular carcinoma (HCC) model. METHODS: 15 male Wistar rats, aged 10 weeks were treated with oral DEN 0.01 % in drinking water and monitored until HCCs were detectable. DCE-MRI and PET were performed consecutively on small animal scanners. 38 tumo...     »
Journal title abbreviation:
Eur J Radiol
Year:
2020
Journal volume:
124
Fulltext / DOI:
doi:10.1016/j.ejrad.2020.108848
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/32006931
Print-ISSN:
0720-048X
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Diagnostische und Interventionelle Radiologie; Klinik und Poliklinik für Nuklearmedizin; Professur für Interventionelle Radiologie (Prof. Paprottka)
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