Psoriasis Pathogenesis: Keratinocytes Are Back in the Spotlight.

Title:: Psoriasis Pathogenesis: Keratinocytes Are Back in the Spotlight.
Document type:: Journal Article; Comment
Author(s):: Garzorz-Stark, Natalie; Eyerich, Kilian
Abstract:: Psoriasis is a T helper type 17-mediated immune disease. Initial triggers that lead to T helper type 17 production and inflammatory cell recruitment into skin are being delineated. Autoantigens that stimulate T helper type 17 cells are also being identified. A new and important piece of the puzzle indicates that keratinocytes not only amplify inflammation, but that they are essential for a full-blown IL-17-mediated psoriatic phenotype in mice.
Journal title abbreviation:: J Invest Dermatol
Year:: 2019
Journal volume:: 139
Journal issue:: 5
Pages contribution:: 995-996
Fulltext / DOI:: doi:10.1016/j.jid.2019.01.026
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/31010530
Print-ISSN:: 0022-202X
TUM Institution:: Klinik und Poliklinik für Dermatologie und Allergologie; Professur für Experimentelle Dermato-Immunologie (Prof. Eyerich)
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