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- Document type:
- Journal Article
- Author(s):
- Guenzinger, Ralf; Lange, Ruediger S; Rieß, Friedrich-Christian; Hanke, Thorsten; Bischoff, Nicolas; Obadia, Jean-Francois; Sahar, Gideon; Bitran, Dani; Roberts, Harold; Li, Shuzhen; Bolling, Steven F
- Title:
- Six-Month Performance of a 3-Dimensional Annuloplasty Ring for Repair of Functional Tricuspid Regurgitation.
- Abstract:
- BACKGROUND: Functional tricuspid regurgitation (FTR) secondary to left-sided heart disease may lead to poor quality of life and reduced long-term survival. This study evaluated clinical and functional outcomes of patients undergoing tricuspid valve (TV) repair using a rigid three-dimensional ring (Contour 3D, Medtronic) concomitant with another procedure. METHODS: From September 2011 to July 2015, 112 patients (mean age 70.9 ± 9.0 years) were enrolled at 10 centers in Europe, Israel, and the United States. Inclusion criteria were FTR ≥ moderate and/or tricuspid annular diameter (TAD) ≥ 40 mm. Echocardiography was planned before surgery and at discharge with echocardiographic and clinical follow-ups performed 6 months postoperatively. RESULTS: Three fourths (74.4%) of patients had higher than moderate TR. Mean TAD was 41.0 ± 7.3 mm; 61.7% of patients were in the New York Heart Association (NYHA) class III/IV. The most common concomitant procedure was mitral valve repair (57 patients, 53.3%). The 30-day mortality rate was 0.9% (n = 1). The mean EuroSCORE II was 8.9 ± 8.4% (median: 5.9%; interquartile range: 3.5-11.5%). The observed to expected ratio (O/E) based on the median was 0.1. Six deaths occurred during follow-up (three cardiac related). Mean implanted ring size was 30.3 ± 2.7. At 6 months, 94.4% of patients showed ≤ mild TR, and 92.0% were in NYHA class I/II (p < 0.001 vs baseline for both). Mean pressure gradient across the TV was 2.0 ± 1.1 mm Hg; leaflet coaptation length was 7.5 ± 3.3 mm. CONCLUSION: The Contour 3D annuloplasty ring used for treatment of FTR substantially reduced TR for up to 6 postoperative months with low mean pressure gradients across the TV and significant improvement in NYHA class. REGISTRATION: www.ClinicalTrials.gov, NCT01532921.
- Journal title abbreviation:
- Thorac Cardiovasc Surg
- Year:
- 2020
- Journal volume:
- 68
- Journal issue:
- 6
- Pages contribution:
- 478-485
- Fulltext / DOI:
- doi:10.1055/s-0038-1673665
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/30452076
- Print-ISSN:
- 0171-6425
- TUM Institution:
- Klinik für Herz- und Gefäßchirurgie (Prof. Lange)
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