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Title:

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

Document type:
Journal Article; Research Support, N.I.H., Extramural
Author(s):
Kilpeläinen, Tuomas O; Bentley, Amy R; Noordam, Raymond; Sung, Yun Ju; Schwander, Karen; Winkler, Thomas W; Jakupović, Hermina; Chasman, Daniel I; Manning, Alisa; Ntalla, Ioanna; Aschard, Hugues; Brown, Michael R; de Las Fuentes, Lisa; Franceschini, Nora; Guo, Xiuqing; Vojinovic, Dina; Aslibekyan, Stella; Feitosa, Mary F; Kho, Minjung; Musani, Solomon K; Richard, Melissa; Wang, Heming; Wang, Zhe; Bartz, Traci M; Bielak, Lawrence F; Campbell, Archie; Dorajoo, Rajkumar; Fisher, Virginia; Hartwig,...     »
Abstract:
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We f...     »
Journal title abbreviation:
Nat Commun
Year:
2019
Journal volume:
10
Journal issue:
1
Fulltext / DOI:
doi:10.1038/s41467-018-08008-w
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30670697
Print-ISSN:
2041-1723
TUM Institution:
Institut für Humangenetik
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