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Title:

Patients with intolerance reactions to total knee replacement: combined assessment of allergy diagnostics, periprosthetic histology, and peri-implant cytokine expression pattern.

Document type:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Thomas, Peter; von der Helm, Christine; Schopf, Christoph; Mazoochian, Farhad; Frommelt, Lars; Gollwitzer, Hans; Schneider, Josef; Flaig, Michael; Krenn, Veit; Thomas, Benjamin; Summer, Burkhard
Abstract:
We performed a combined approach to identify suspected allergy to knee arthroplasty (TKR): patch test (PT), lymphocyte transformation test (LTT), histopathology (overall grading; T- and B-lymphocytes, macrophages, and neutrophils), and semiquantitative Real-time-PCR-based periprosthetic inflammatory mediator analysis (IFN?, TNF?, IL1-?, IL-2, IL-6, IL-8, IL-10, IL17, and TGF?). We analyzed 25 TKR patients with yet unexplained complications like pain, effusion, and reduced range of motion. They...     »
Journal title abbreviation:
Biomed Res Int
Year:
2015
Journal volume:
2015
Pages contribution:
910156
Language:
eng
Fulltext / DOI:
doi:10.1155/2015/910156
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25866822
Print-ISSN:
2314-6133
TUM Institution:
Klinik und Poliklinik für Orthopädie und Sportorthopädie
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