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Title:

Variable transcriptional activity of endogenous retroviruses in human breast cancer.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Frank, O; Verbeke, C; Schwarz, N; Mayer, J; Fabarius, A; Hehlmann, R; Leib-Mösch, C; Seifarth, W
Abstract:
Human endogenous retroviruses (HERVs) account for up to 9% of the human genome and include more than 800 elements related to betaretroviruses. While mouse mammary tumor virus (MMTV) is the accepted etiological agent of mammary tumors in mice, the role of retroviral elements in human breast cancer remains elusive. Here, we performed a comprehensive microarray-based analysis of overall retroviral transcriptional activities in 46 mammary gland tissue specimens representing pairs of nonmalignant and...     »
Journal title abbreviation:
J Virol
Year:
2008
Journal volume:
82
Journal issue:
4
Pages contribution:
1808-18
Language:
eng
Fulltext / DOI:
doi:10.1128/JVI.02115-07
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18077721
Print-ISSN:
0022-538X
TUM Institution:
Institut für Virologie
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