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Title:

In vivo attenuation of recombinant murine gammaherpesvirus 68 (MHV-68) is due to the expression and immunogenicity but not to the insertion of foreign sequences.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
El-Gogo, S; Flach, B; Staib, C; Sutter, G; Adler, H
Abstract:
Recombinant herpesviruses are increasingly utilized to study herpesvirus biology. For recombinant viruses carrying insertions of foreign sequences, attenuated phenotypes in vivo have been frequently observed. In most cases, the underlying mechanisms were not clear or have not been investigated. In this study, we used a recombinant murine gammaherpesvirus 68 (MHV-68), carrying a cassette for the expression of the non-structural protein NS3 of Hepatitis C virus (MHV-68-NS3), to systematically addr...     »
Journal title abbreviation:
Virology
Year:
2008
Journal volume:
380
Journal issue:
2
Pages contribution:
322-7
Language:
eng
Fulltext / DOI:
doi:10.1016/j.virol.2008.07.034
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18774154
Print-ISSN:
0042-6822
TUM Institution:
Institut für Virologie
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