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Title:

A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Schulze, K; Staib, C; Schätzl, HM; Ebensen, T; Erfle, V; Guzman, CA
Abstract:
Severe acute respiratory syndrome (SARS) is a serious infectious disease caused by the SARS coronavirus. We assessed the potential of prime-boost vaccination protocols based on the nucleocapsid (NC) protein co-administered with a derivative of the mucosal adjuvant MALP-2 or expressed by modified Vaccinia virus Ankara (MVA-NC) to stimulate humoral and cellular immune responses at systemic and mucosal levels. The obtained results demonstrated that strong immune responses can be elicited both at sy...     »
Journal title abbreviation:
Vaccine
Year:
2008
Journal volume:
26
Journal issue:
51
Pages contribution:
6678-84
Language:
eng
Fulltext / DOI:
doi:10.1016/j.vaccine.2008.09.006
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/18805454
Print-ISSN:
0264-410X
TUM Institution:
Institut für Virologie
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