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Titel:

In vivo attenuation of recombinant murine gammaherpesvirus 68 (MHV-68) is due to the expression and immunogenicity but not to the insertion of foreign sequences.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
El-Gogo, S; Flach, B; Staib, C; Sutter, G; Adler, H
Abstract:
Recombinant herpesviruses are increasingly utilized to study herpesvirus biology. For recombinant viruses carrying insertions of foreign sequences, attenuated phenotypes in vivo have been frequently observed. In most cases, the underlying mechanisms were not clear or have not been investigated. In this study, we used a recombinant murine gammaherpesvirus 68 (MHV-68), carrying a cassette for the expression of the non-structural protein NS3 of Hepatitis C virus (MHV-68-NS3), to systematically addr...     »
Zeitschriftentitel:
Virology
Jahr:
2008
Band / Volume:
380
Heft / Issue:
2
Seitenangaben Beitrag:
322-7
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.virol.2008.07.034
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18774154
Print-ISSN:
0042-6822
TUM Einrichtung:
Institut für Virologie
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