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Titel:

A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Schulze, K; Staib, C; Schätzl, HM; Ebensen, T; Erfle, V; Guzman, CA
Abstract:
Severe acute respiratory syndrome (SARS) is a serious infectious disease caused by the SARS coronavirus. We assessed the potential of prime-boost vaccination protocols based on the nucleocapsid (NC) protein co-administered with a derivative of the mucosal adjuvant MALP-2 or expressed by modified Vaccinia virus Ankara (MVA-NC) to stimulate humoral and cellular immune responses at systemic and mucosal levels. The obtained results demonstrated that strong immune responses can be elicited both at sy...     »
Zeitschriftentitel:
Vaccine
Jahr:
2008
Band / Volume:
26
Heft / Issue:
51
Seitenangaben Beitrag:
6678-84
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.vaccine.2008.09.006
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/18805454
Print-ISSN:
0264-410X
TUM Einrichtung:
Institut für Virologie
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