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Titel:

Transduction of human neural progenitor cells with foamy virus vectors for differentiation-dependent gene expression.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Rothenaigner, I; Kramer, S; Meggendorfer, M; Rethwilm, A; Brack-Werner, R
Abstract:
Neural progenitor cells are potential vehicles for delivery of therapeutic agents into the brain. Differentiation-dependent promoters may be useful to target the therapeutic transgene expression to specific neural cell types. Here we explored the potential of vectors based on the foamy virus (FV) for genetic engineering of neural progenitor cells. We demonstrate that FV vectors can mediate stable long-term constitutive expression of the enhanced green fluorescent protein (EGFP) in neural progeni...     »
Zeitschriftentitel:
Gene Ther
Jahr:
2009
Band / Volume:
16
Heft / Issue:
3
Seitenangaben Beitrag:
349-58
Sprache:
eng
Volltext / DOI:
doi:10.1038/gt.2008.173
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19052634
Print-ISSN:
0969-7128
TUM Einrichtung:
Institut für Virologie
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