Benutzer: Gast  Login
Titel:

Inhibition of prion amplification by expression of dominant inhibitory mutants--a systematic insertion mutagenesis study.

Dokumenttyp:
Journal Article
Autor(en):
Geissen, M; Mella, H; Saalmüller, A; Eiden, M; Proft, J; Pfaff, E; Schätzl, HM; Groschup, MH
Abstract:
Until now it is still not clear which structural elements of the prion protein (PrP) are involved in its conversion process. Characterisation of these essential regions would help to understand the conversion process itself and might help to develop specific therapeutic approaches to inhibit PrP(res) formation by dominant inhibitory mutations. To address this important question 33 evenly spaced insertion mutants were generated spanning the entire sequence of the murine 3F4-tagged PrP. The mutant...     »
Zeitschriftentitel:
Infect Disord Drug Targets
Jahr:
2009
Band / Volume:
9
Heft / Issue:
1
Seitenangaben Beitrag:
40-7
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19200014
Print-ISSN:
1871-5265
TUM Einrichtung:
Institut für Virologie
 BibTeX