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Titel:

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Heiseke, A; Aguib, Y; Riemer, C; Baier, M; Schätzl, HM
Abstract:
Lithium is used for several decades to treat manic-depressive illness (bipolar affective disorder). Recently, it was found that lithium induces autophagy, thereby promoting the clearance of mutant huntingtin and alpha-synucleins in experimental systems. We show here for the first time that lithium significantly reduces the amount of pathological prion protein (PrP(Sc)) in prion-infected neuronal and non-neuronal cultured cells by inducing autophagy. Treatment of prion-infected cells with 3-methy...     »
Zeitschriftentitel:
J Neurochem
Jahr:
2009
Band / Volume:
109
Heft / Issue:
1
Seitenangaben Beitrag:
25-34
Sprache:
eng
Volltext / DOI:
doi:10.1111/j.1471-4159.2009.05906.x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19183256
Print-ISSN:
0022-3042
TUM Einrichtung:
Institut für Virologie
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