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Title:

Novel regulation of HIV-1 replication and pathogenicity: Rev inhibition of integration.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Levin, A; Hayouka, Z; Brack-Werner, R; Volsky, DJ; Friedler, A; Loyter, A
Abstract:
Following fusion of the human immunodeficiency virus type-1 (HIV-1) with host cells' membrane and reverse transcription of the viral RNA, the resulted cDNA is integrated into the host genome by the viral integrase enzyme (IN). Quantitative estimations have revealed that only 1-2 copies are integrated per infected cell, although many copies of the viral RNA are reverse-transcribed. The molecular mechanism that restricts the integration degree has not, so far, been elucidated. Following integratio...     »
Journal title abbreviation:
Protein Eng Des Sel
Year:
2009
Journal volume:
22
Journal issue:
12
Pages contribution:
753-63
Language:
eng
Fulltext / DOI:
doi:10.1093/protein/gzp060
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19875511
Print-ISSN:
1741-0126
TUM Institution:
Institut für Virologie
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