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Titel:

Autophagy induction by trehalose counteracts cellular prion infection.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Aguib, Y; Heiseke, A; Gilch, S; Riemer, C; Baier, M; Schätzl, HM; Ertmer, A
Abstract:
Prion diseases are fatal neurodegenerative and infectious disorders for which no therapeutic or prophylactic regimens exist. In search of cellular mechanisms that play a role in prion diseases and have the potential to interfere with accumulation of intracellular pathological prion protein (PrP(Sc)), we investigated the autophagic pathway and one of its recently published inducers, trehalose. Trehalose, an alpha-linked disaccharide, has been shown to accelerate clearance of mutant huntingtin and...     »
Zeitschriftentitel:
Autophagy
Jahr:
2009
Band / Volume:
5
Heft / Issue:
3
Seitenangaben Beitrag:
361-9
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19182537
Print-ISSN:
1554-8627
TUM Einrichtung:
Institut für Virologie
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