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Title:

Derivation of inhalation toxicity reference values for propylene oxide using mode of action analysis: example of a threshold carcinogen.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Sweeney, LM; Kirman, CR; Albertini, RJ; Tan, YM; Clewell, HJ; Filser, JG; Csanady, G; Pottenger, LH; Banton, MI; Graham, CJ; Andrews, LS; Papciak, RJ; Gargas, ML
Abstract:
Propylene oxide (PO) is an important industrial chemical used primarily in the synthesis of other compounds. Inhalation carcinogenesis studies in rodents, with no-observed-adverse-effect levels (NOAELs) of 100 and 200 ppm, have revealed that chronic, high exposure to PO can induce tumors at the site of contact. Despite these characteristics, there is no evidence that typical environmental or occupational exposures to PO constitute a health risk for humans. The nongenotoxic effects of PO (glutath...     »
Journal title abbreviation:
Crit Rev Toxicol
Year:
2009
Journal volume:
39
Journal issue:
6
Pages contribution:
462-86
Language:
eng
Fulltext / DOI:
doi:10.1080/10408440902837959
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19545197
Print-ISSN:
1040-8444
TUM Institution:
Institut für Toxikologie und Umwelthygiene
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