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Titel:

IGFBP-2 overexpression reduces the appearance of dysplastic aberrant crypt foci and inhibits growth of adenomas in chemically induced colorectal carcinogenesis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Diehl, D; Hessel, E; Oesterle, D; Renner-Müller, I; Elmlinger, M; Langhammer, M; Göttlicher, M; Wolf, E; Lahm, H; Hoeflich, A
Abstract:
Colon cancer patients frequently show increased levels of serum insulin-like growth factor-binding protein-2 (IGFBP-2), however, the pathogenetic relevance of this phenomenon for colorectal cancer is unclear. Therefore, we have used IGFBP-2 transgenic animals which overexpress IGFBP-2 systemically and locally in the intestine to study its role in chemically induced colorectal carcinogenesis. Mice received intraperitoneal injections of 1,2-dimethylhydrazine (DMH) (40 mg/kg body weight) once a wee...     »
Zeitschriftentitel:
Int J Cancer
Jahr:
2009
Band / Volume:
124
Heft / Issue:
9
Seitenangaben Beitrag:
2220-5
Sprache:
eng
Volltext / DOI:
doi:10.1002/ijc.24193
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/19142966
Print-ISSN:
0020-7136
TUM Einrichtung:
Institut für Toxikologie und Umwelthygiene
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