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Title:

Not interferon, but interleukin-6 controls early gene expression in hepatitis B virus infection.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Hösel, M; Quasdorff, M; Wiegmann, K; Webb, D; Zedler, U; Broxtermann, M; Tedjokusumo, R; Esser, K; Arzberger, S; Kirschning, CJ; Langenkamp, A; Falk, C; Büning, H; Rose-John, S; Protzer, U
Abstract:
With about 350 million virus carriers, hepatitis B virus (HBV) infection remains a major health problem. HBV is a noncytopathic virus causing persistent infection, but it is still unknown whether host recognition of HBV may activate an innate immune response. We describe that upon infection of primary human liver cells, HBV is recognized by nonparenchymal cells of the liver, mainly by liver macrophages (Kupffer cells), although they are not infected. Within 3 hours, this recognition leads to the...     »
Journal title abbreviation:
Hepatology
Year:
2009
Journal volume:
50
Journal issue:
6
Pages contribution:
1773-82
Language:
eng
Fulltext / DOI:
doi:10.1002/hep.23226
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19937696
Print-ISSN:
0270-9139
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Institut für Virologie
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