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Titel:

Neuronal cGMP kinase I is essential for stimulation of duodenal bicarbonate secretion by luminal acid.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Singh, AK; Spiessberger, B; Zheng, W; Xiao, F; Lukowski, R; Wegener, JW; Weinmeister, P; Saur, D; Klein, S; Schemann, M; Krueger, D; Seidler, U; Hofmann, F
Abstract:
Brief contact of the duodenal mucosa with luminal acid elicits a long-lasting bicarbonate (HCO(3)(-)) secretory response, which is believed to be the primary protective mechanism against mucosal damage. Here, we show that cGMP-dependent protein kinase type I-knockout (cGKI(-/-)) mice are unable to respond to a physiological H(+) stimulus with a HCO(3)(-) secretory response and spontaneously develop duodenal ulcerations. Smooth muscle-selective cGKI knock-in rescued the motility disturbance but n...     »
Zeitschriftentitel:
FASEB J
Jahr:
2012
Band / Volume:
26
Heft / Issue:
4
Seitenangaben Beitrag:
1745-54
Sprache:
eng
Volltext / DOI:
doi:10.1096/fj.11-200394
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22253479
Print-ISSN:
0892-6638
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Pharmakologie und Toxikologie
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