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Title:

?-adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Jaffre, F; Friedman, AE; Hu, Z; Mackman, N; Blaxall, BC
Abstract:
Chronic ?-adrenergic receptor (?-AR) overstimulation, a hallmark of heart failure, is associated with increased cardiac expression of matrix metalloproteinases (MMPs). MMP-1 has been shown to cleave and activate the protease-activated receptor 1 (PAR1) in noncardiac cells. In the present study, we hypothesized that ?-AR stimulation would result in MMP-dependent PAR1 transactivation in cardiac cells.?-AR stimulation of neonatal rat ventricular myocytes (NRVMs) or cardiac fibroblasts with isoprote...     »
Journal title abbreviation:
Circulation
Year:
2012
Journal volume:
125
Journal issue:
24
Pages contribution:
2993-3003
Language:
eng
Fulltext / DOI:
doi:10.1161/CIRCULATIONAHA.111.066787
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22610965
Print-ISSN:
0009-7322
TUM Institution:
Institut für Pharmakologie und Toxikologie
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