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- Titel:
Nuclear matrix protein 22 for bladder cancer detection: comparative analysis of the BladderChek® and ELISA.
- Dokumenttyp:
- Journal Article; Article
- Autor(en):
- Hatzichristodoulou, G; Kubler, H; Schwaibold, H; Wagenpfeil, S; Eibauer, C; Hofer, C; Gschwend, J; Treiber, U
- Abstract:
- To compare nuclear matrix protein 22 expression by BladderChek® and ELISA, as urine-based assays for bladder cancer (BC) detection.Urine samples of 100 BC patients and 100 controls were analyzed. Comparative statistical evaluations were based on sensitivity and specificity.Seventy-one patients had primary and 29 recurrent BC. The sensitivity of BladderChek® was significantly higher compared to ELISA in the overall cancer cohort and in patients with primary BC (p<0.0001 and p=0.0001, respectively). Both tests demonstrated significant correlation of sensitivities and tumor stage/grade for the overall cancer cohort and for patients with primary BC. Both tests had specificity values of 100% in healthy individuals. Specificity was 93% for BladderChek® and 99% for ELISA in patients with benign diseases (p=0.048).BladderChek® may be clinically more useful for BC detection. Due to high specificity, BladderChek® could be used for high-risk screening. However, due to its low sensitivity, BladderChek® cannot replace but only complement cystoscopy for BC detection.
- Zeitschriftentitel:
- Anticancer Res
- Jahr:
- 2012
- Band / Volume:
- 32
- Heft / Issue:
- 11
- Seitenangaben Beitrag:
- 5093-7
- Sprache:
- eng
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/23155286
- Print-ISSN:
- 0250-7005
- TUM Einrichtung:
- Institut für Medizinische Statistik und Epidemiologie; Urologische Klinik und Poliklinik
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