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Title:

Specific activity of cyclin-dependent kinase I is a new potential predictor of tumour recurrence in stage II colon cancer.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Zeestraten, EC; Maak, M; Shibayama, M; Schuster, T; Nitsche, U; Matsushima, T; Nakayama, S; Gohda, K; Friess, H; van de Velde, CJ; Ishihara, H; Rosenberg, R; Kuppen, PJ; Janssen, KP
Abstract:
There are no established biomarkers to identify tumour recurrence in stage II colon cancer. As shown previously, the enzymatic activity of the cyclin-dependent kinases 1 and 2 (CDK1 and CDK2) predicts outcome in breast cancer. Therefore, we investigated whether CDK activity identifies tumour recurrence in colon cancer.In all, 254 patients with completely resected (R0) UICC stage II colon cancer were analysed retrospectively from two independent cohorts from Munich (Germany) and Leiden (Netherlan...     »
Journal title abbreviation:
Br J Cancer
Year:
2012
Journal volume:
106
Journal issue:
1
Pages contribution:
133-40
Language:
eng
Fulltext / DOI:
doi:10.1038/bjc.2011.504
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22108518
Print-ISSN:
0007-0920
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Medizinische Statistik und Epidemiologie
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