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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
van Helden, MJ; van Kooten, PJ; Bekker, CP; Gröne, A; Topham, DJ; Easton, AJ; Boog, CJ; Busch, DH; Zaiss, DM; Sijts, AJ 
Title:
Pre-existing virus-specific CD8(+) T-cells provide protection against pneumovirus-induced disease in mice. 
Abstract:
Pneumoviruses such as pneumonia virus of mice (PVM), bovine respiratory syncytial virus (bRSV) or human (h)RSV are closely related pneumoviruses that cause severe respiratory disease in their respective hosts. It is well-known that T-cell responses are essential in pneumovirus clearance, but pneumovirus-specific T-cell responses also are important mediators of severe immunopathology. In this study we determined whether memory- or pre-existing, transferred virus-specific CD8(+) T-cells provide pr...    »
 
Journal title abbreviation:
Vaccine 
Year:
2012 
Journal volume:
30 
Journal issue:
45 
Pages contribution:
6382-8 
Language:
eng 
Print-ISSN:
0264-410X 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene