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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Oldenburg, M; Kruger, A; Ferstl, R; Kaufmann, A; Nees, G; Sigmund, A; Bathke, B; Lauterbach, H; Suter, M; Dreher, S; Koedel, U; Akira, S; Kawai, T; Buer, J; Wagner, H; Bauer, S; Hochrein, H; Kirschning, CJ 
Title:
TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification. 
Abstract:
Host protection from infection relies on the recognition of pathogens by innate pattern-recognition receptors such as Toll-like receptors (TLRs). Here, we show that the orphan receptor TLR13 in mice recognizes a conserved 23S ribosomal RNA (rRNA) sequence that is the binding site of macrolide, lincosamide, and streptogramin group (MLS) antibiotics (including erythromycin) in bacteria. Notably, 23S rRNA from clinical isolates of erythromycin-resistant Staphylococcus aureus and synthetic oligoribo...    »
 
Journal title abbreviation:
Science 
Year:
2012 
Journal volume:
337 
Journal issue:
6098 
Pages contribution:
1111-5 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0036-8075 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene 
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