Benutzer: Gast  Login
Titel:

Cytochrome c oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology.

Dokumenttyp:
Journal Article; Article
Autor(en):
Hüttemann, M; Lee, I; Gao, X; Pecina, P; Pecinova, A; Liu, J; Aras, S; Sommer, N; Sanderson, TH; Tost, M; Neff, F; Aguilar-Pimentel, JA; Becker, L; Naton, B; Rathkolb, B; Rozman, J; Favor, J; Hans, W; Prehn, C; Puk, O; Schrewe, A; Sun, M; Höfler, H; Adamski, J; Bekeredjian, R; Graw, J; Adler, T; Busch, DH; Klingenspor, M; Klopstock, T; Ollert, M; Wolf, E; Fuchs, H; Gailus-Durner, V; Hrabé de Angelis, M; Weissmann, N; Doan, JW; Bassett, DJ; Grossman, LI
Abstract:
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial electron transport chain. The purpose of this study was to analyze the function of lung-specific cytochrome c oxidase subunit 4 isoform 2 (COX4i2) in vitro and in COX4i2-knockout mice in vivo. COX was isolated from cow lung and liver as control and functionally analyzed. COX4i2-knockout mice were generated and the effect of the gene knockout was determined, including COX activity, tissue energy levels, noninvasive and invasiv...     »
Zeitschriftentitel:
FASEB J
Jahr:
2012
Band / Volume:
26
Heft / Issue:
9
Seitenangaben Beitrag:
3916-30
Sprache:
eng
Volltext / DOI:
doi:10.1096/fj.11-203273
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22730437
Print-ISSN:
0892-6638
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
 BibTeX