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Title:

Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Schwandt, T; Schumak, B; Gielen, GH; Jüngerkes, F; Schmidbauer, P; Klocke, K; Staratschek-Jox, A; van Rooijen, N; Kraal, G; Ludwig-Portugall, I; Franken, L; Wehner, S; Kalff, JC; Weber, O; Kirschning, C; Coch, C; Kalinke, U; Wenzel, J; Kurts, C; Zawatzky, R; Holzmann, B; Layland, L; Schultze, JL; Burgdorf, S; den Haan, JM; Knolle, PA; Limmer, A
Abstract:
Early during Gram-negative sepsis, excessive release of pro-inflammatory cytokines can cause septic shock that is often followed by a state of immune paralysis characterized by the failure to mount adaptive immunity towards secondary microbial infections. Especially, the early mechanisms responsible for such immune hypo-responsiveness are unclear. Here, we show that TLR4 is the key immune sensing receptor to initiate paralysis of T-cell immunity after bacterial sepsis. Downstream of TLR4, signal...     »
Journal title abbreviation:
EMBO J
Year:
2012
Journal volume:
31
Journal issue:
1
Pages contribution:
201-13
Language:
eng
Fulltext / DOI:
doi:10.1038/emboj.2011.380
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22036947
Print-ISSN:
0261-4189
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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