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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't 
Autor(en):
Grunewald, TG; Diebold, I; Esposito, I; Plehm, S; Hauer, K; Thiel, U; Da Silva-Buttkus, P; Neff, F; Unland, R; Müller-Tidow, C; Zobywalski, C; Lohrig, K; Lewandrowski, U; Sickmann, A; da Costa, OP; Gorlach, A; Cossarizza, A; Butt, E; Richter, GH; Burdach, S 
Titel:
STEAP1 is associated with the invasive and oxidative stress phenotype of Ewing tumors. 
Abstract:
Ewing tumors comprise the second most common type of bone-associated cancer in children and are characterized by oncogenic EWS/FLI1 fusion proteins and early metastasis. Compelling evidence suggests that elevated levels of intracellular oxidative stress contribute to enhanced aggressiveness of numerous cancers, possibly including Ewing tumors. Using comprehensive microarray analyses and RNA interference, we identified the six-transmembrane epithelial antigen of the prostate 1 (STEAP1)-a membrane...    »
 
Zeitschriftentitel:
Mol Cancer Res 
Jahr:
2012 
Band / Volume:
10 
Heft / Issue:
Seitenangaben Beitrag:
52-65 
Sprache:
eng 
Print-ISSN:
1541-7786 
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene; Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess); Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin 
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