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Titel:

A new strategy for the development of monoclonal antibodies for the determination of human procalcitonin in serum samples.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Kremmer, E; Meyer, K; Grässer, FA; Flatley, A; Kösters, M; Luppa, PB; Krämer, PM
Abstract:
Procalcitonin (PCT)-a diagnostic serum parameter for bacterial infection and sepsis-is of great interest in the field of biosensors for point-of-care testing. Its detection needs specific biological recognition elements, such as antibodies. Herein, we describe the development and characterization of rat monoclonal antibodies (mAbs) for PCT, and their application in enzyme-linked immunosorbent assays (ELISAs) for the determination of PCT in patient serum samples. From about 50 mAbs, two mAbs, CAL...     »
Zeitschriftentitel:
Anal Bioanal Chem
Jahr:
2012
Band / Volume:
402
Heft / Issue:
2
Seitenangaben Beitrag:
989-95
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00216-011-5475-4
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22006244
Print-ISSN:
1618-2642
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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