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Titel:

Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial.

Dokumenttyp:
Journal Article; Article
Autor(en):
Rödel, C; Liersch, T; Becker, H; Fietkau, R; Hohenberger, W; Hothorn, T; Graeven, U; Arnold, D; Lang-Welzenbach, M; Raab, HR; Sülberg, H; Wittekind, C; Potapov, S; Staib, L; Hess, C; Weigang-Köhler, K; Grabenbauer, GG; Hoffmanns, H; Lindemann, F; Schlenska-Lange, A; Folprecht, G; Sauer, R
Abstract:
BACKGROUND: Preoperative chemoradiotherapy, total mesorectal excision surgery, and adjuvant chemotherapy with fluorouracil is the standard combined modality treatment for rectal cancer. With the aim of improving disease-free survival (DFS), this phase 3 study (CAO/ARO/AIO-04) integrated oxaliplatin into standard treatment. METHODS: This was a multicentre, open-label, randomised, phase 3 study in patients with histologically proven carcinoma of the rectum with clinically staged T3-4 or any node-p...     »
Zeitschriftentitel:
Lancet Oncol
Jahr:
2012
Band / Volume:
13
Heft / Issue:
7
Seitenangaben Beitrag:
679-687
Sprache:
eng
Volltext / DOI:
doi:10.1016/S1470-2045(12)70187-0
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22627104
Print-ISSN:
1470-2045
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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