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Titel:

The adaptor protein FADD and the initiator caspase-8 mediate activation of NF-?B by TRAIL.

Dokumenttyp:
Journal Article
Autor(en):
Grunert, M; Gottschalk, K; Kapahnke, J; Gundisch, S; Kieser, A; Jeremias, I
Abstract:
Besides inducing apoptosis, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) activates NF-?B. The apoptosis signaling pathway of TRAIL is well characterized involving TRAIL receptors, Fas-associated protein with death domain (FADD) and caspase-8. In contrast, the molecular mechanism of TRAIL signaling to NF-?B remains controversial. Here, we characterized the receptor-proximal mediators of NF-?B activation by TRAIL. Deletion of the DD of TRAIL receptors 1 and 2 revealed that it is...     »
Zeitschriftentitel:
Cell Death Dis
Jahr:
2012
Band / Volume:
3
Seitenangaben Beitrag:
e414
Sprache:
eng
Volltext / DOI:
doi:10.1038/cddis.2012.154
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23096115
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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